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While several CVOTs were performed with injectable GLP-1 RAs [46], the recent SOUL trial assessed the use of oral semaglutide, which was associated with a significantly lower risk of MACE than a placebo, without an increase in the incidence of serious adverse events, in patients with T2D and atherosclerotic cardiovascular disease (ASCVD), CKD, or both [71]

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It is important to inform us of any allergies, medical conditions, or medications you are currently taking to avoid potential contraindications

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

And Eli Lilly reports no specific evidence that Zepbound or Mounjaro increase fracture risk , and fractures are not listed as a safety signal in the current US prescribing information, although they continue to monitor safety data